Amino acid modulated extended release dosage form

Details Amino acid modulated extended release dosage form Amino acid modulated extended release dosage form

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2459014

Disclosed herein is an oral extended release dosage form, such as a tablet, comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristic of the active compound.

L'invention concerne une forme posologique à administration orale de type comprimé à libération modifiée comprenant une pluralité de granules ayant une quantité efficace d'un composé pharmaceutiquement actif, au moins un acide aminé et un polymère intragranulaire où le granule est dispersé dans une matrice polymère extragranulaire hydrophile s'hydratant plus rapidement que le polymère intragranulaire. L'acide aminé est sélectionné en raison de ces caractéristiques d'hydropathie dépendant des caractéristiques de solubilité du composé actif.

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