Amino acid sequences directed against fc receptors and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2672770

The present invention relates to amino acid sequences that are directed against (as defined herein) receptors for proteins with an immunoglobulin fold (Fc receptors), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic puiposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

Cette invention concerne des séquences d'acides aminés dirigées contre des récepteurs pour des protéines présentant un pli d'immunoglobuline (récepteurs Fc), ainsi que des composés ou des constructions, et plus particulièrement des protéines et des polypeptides, qui comprennent ou consistent essentiellement en une ou plusieurs séquences d'acides aminés. Cette invention concerne également des acides nucléiques codant pour de telles séquences acides aminés et pour de tels polypeptides. L'invention concerne également des procédés permettant de préparer de telles séquences d'acides aminés et de tels polypeptides; des cellules hôtes exprimant ou capable d'exprimer de telles séquences d'acides aminés ou de tels polypeptides; des compositions, et plus particulièrement des compositions pharmaceutiques, comprenant ces séquences d'acides aminés, ces polypeptides, ces acides nucléiques et/ou ces cellules hôtes. L'invention concerne également des procédés permettant d'utiliser ces séquences d'acides aminés ou ces polypeptides, ces acides nucléiques, ces cellules hôtes et/ou ces compositions, plus particulièrement pour des applications prophylactiques, thérapeutiques ou diagnostiques, tels que celles mentionnées dans cette invention.

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