C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2644405
The present invention relates to amino acid sequences that are directed against interleukin-6 (IL-6), as well as to compounds or constructs, and in particular proteins and polypeptides that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
La présente invention concerne des séquences d'acides aminés dirigées contre l'interleukine-6 (IL-6), ainsi que des composés ou des assemblages, et en particulier des protéines et des polypeptides qui comprennent ou sont sensiblement constitués d'une ou de plusieurs de ces séquences d'acides aminés. L'invention concerne également des acides nucléiques codant pour de telles séquences d'acides aminés et de tels polypeptides, des méthodes d'élaboration de telles séquences d'acides aminés et de tels polypeptides ; des cellules hôtes exprimant ou capables d'exprimer de telles séquences d'acides aminés ou de tels polypeptides ; des compositions, et en particulier des compositions pharmaceutiques, qui comprennent de telles séquences d'acides aminés, de tels polypeptides, de tels acides nucléiques et/ou de telles cellules hôtes ; et les applications de telles séquences d'acides aminés, de tels polypeptides, de tels acides nucléiques, de telles cellules hôtes et/ou de telles compositions, en particulier à des fins prophylactiques, thérapeutiques ou de diagnostic.
Hermans Guy
Hoogenboom Hendricus Renerus Jacobus Matteus
Kolkman Joost Alexander
Ablynx N.v.
Borden Ladner Gervais Llp
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