C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/518, 260/539
C07D 265/12 (2006.01) C07C 101/14 (1980.01)
Patent
CA 1087185
ABSTRACT A process is described for the preparation of compounds of the general formula Image and their salts, where R and R1 are independently hydrogen or lower alkyl and n is an integer from 1 to 5, wherein a ketone of formula Image where R, R1 and n are as defined above is reacted with an ammonium salt of malonic acid. If desired, a removable blocking group for the amino group is introduced. The invention also includes preparation of a derivatives of the products useful a acylating agents. The products of the process are useful as intermediates for the preparation of 6-[2-(1-aminocycloalkyl)acetamido]penicillanic acids. - 1 -
159105
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
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