Amino acids and peptides having modified terminals

Details Amino acids and peptides having modified terminals Amino acids and peptides having modified terminals

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 31/165 (2006.01) A61K 38/04 (2006.01) C07C 237/20 (2006.01) C07C 279/12 (2006.01) C07C 279/14 (2006.01) C07C 279/36 (2006.01) C07C 323/44 (2006.01)

Patent

CA 2153987

Compounds which have one of structural formulae (I) or (II). AA is an amino acid residue or an amino acid chain of two or more amino acid residues, excluding the N-terminal and the C-terminal from said amino acid residue or amino acid chain of two or more amino acid residues; R1 is hydrogen or an alkyl group having from 1 to 8 carbon atoms; R2 is selected from the group consisting of (i) a substituted or unsubstituted hydrocarbon having from 1 to 20 carbon atoms, and (ii) (a). R4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms. R4 may be substituted or unsubstituted. R3 is selected from the group consisting of (i) hydrogen; (ii) (b), wherein R5 is hydrogen or a nitro group; and (iii) (c), wherein each of R6, R7, and R8 is hydrogen or methyl. The above compounds are useful as pharmaceuticals for inhibiting the growth of target cells, viruses, or virally-infected cells.

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