Amino alcohol derivative and method for preparing the same

Details Amino alcohol derivative and method for preparing the same Amino alcohol derivative and method for preparing the same

C - Chemistry, Metallurgy

07

D

C07D 295/13 (2006.01) C07B 53/00 (2006.01) C07C 215/18 (2006.01) C07C 231/02 (2006.01) C07C 231/18 (2006.01) C07C 233/36 (2006.01) C07C 271/20 (2006.01) C07C 309/66 (2006.01) C07D 207/04 (2006.01) C07D 207/08 (2006.01) C07D 207/12 (2006.01) C07D 211/22 (2006.01) C07D 211/44 (2006.01) C07D 211/46 (2006.01) C07D 241/04 (2006.01) C07D 265/30 (2006.01) C07D 295/125 (2006.01)

Patent

CA 2192268

A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y-CH2-C*H(NHP1)-C*H(OH)-R1 (1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2-CH2-C*H(NHP1)-C*H(OH)-R1 (2) (B) leaving P1 from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2-CH2-C*H(NH2)-C*H(OH)-R1 (3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2-CH2-C*H(NHCOR11)-C*H(OH)-R1(4) wherein * represents an asymmetric carbon atom, and P1, R1, R 2 and R" are defined in the specification. A process for preparing alcohol derivatives having an acylamino group through several steps from amino group-protected 2-aminopropanol derivatives, and novel amino alcohols useful as intermediates in the process for preparing the alcohol derivative.

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