Amino and substituted amino phosphinylalkanoyl compounds

C - Chemistry – Metallurgy – 07 – F

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260/291, 260/468

C07F 9/30 (2006.01) C07F 9/58 (2006.01)

Patent

CA 1204757

ABSTRACT A compound of the formula (II): Image (II) wherein R1 is R19-?- or R20-O-?-; n is zero or one; R5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl; and R3 is hydrogen, lower alkyl, benzyl, or benz- hydryl. These compounds are useful as intermediates in the preparation of compounds of the formula: Image wherein X is an imino acid or ester and R1 is hydro- gen, R19-?- or R20-O-?- which are useful hypoten- sive agents due to their angiotensin converting en- zyme inhibition activity.

478096

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