Amino anthracenediones-bis platinum complexes, useful as...

Details Amino anthracenediones-bis platinum complexes, useful as... Amino anthracenediones-bis platinum complexes, useful as...

C - Chemistry, Metallurgy

07

F

167/119, 260/210

C07F 15/00 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1327355

Abstract The present invention provides bis-platinum complexes of formula I Image (I) wherein A is a disubstituted 1,4-anthracenedione; X, X' are ligands selected from the group consisting of Cl, Br, OH, CH3SOCH3?OH or CH3SOCH3?Hal or, taken together, form the anion of a dicarboxylic acid; m is zero, 0.5 or an integer from 1 to 5; Solv. is a solvent of crystallization which may optionally be present; Ra is hydrogen, alkyl optionally substituted by hydroxy groups and/or interrupted by oxygen atoms; Rb is alkyl optionally substituted by hydroxy, alkoxy, polyalkoxy or sulphonic groups or a residue of an amino-sugar and n is an integer from 2 to 3. The compounds of formula I are useful as anti-tumor agents.

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