Amino arylsulfonamide compounds and their use as 5-ht6 ligands

Details Amino arylsulfonamide compounds and their use as 5-ht6 ligands Amino arylsulfonamide compounds and their use as 5-ht6 ligands

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61P 25/14 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2703157

The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

La présente invention porte sur de nouveaux composés d'aminoarylsulfonamide représentés par la formule (I), sur leurs dérivés, sur leurs stéréoisomères, sur leurs sels pharmaceutiquement acceptables et sur des compositions pharmaceutiquement acceptables les contenant. La présente invention porte également sur un procédé de préparation des nouveaux composés susmentionnés, de leurs dérivés, de leurs stéréoisomères, de leurs sels pharmaceutiquement acceptables et de compositions pharmaceutiquement acceptables les contenant. Les composés proposés par l'invention sont utiles dans le traitement de divers états liés aux fonctions du récepteur 5-HT6. De façon spécifique, les composés proposés par la présente invention sont également utiles dans le traitement de divers troubles du SNC, de troubles hématologiques, de troubles de l'alimentation, de l'obésité, de l'anxiété, de la dépression, de maladies associées à la douleur, de maladies respiratoires, de maladies gastro-intestinales, cardiovasculaires et du cancer.

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