Amino benzamides

Details Amino benzamides Amino benzamides

C - Chemistry, Metallurgy

07

C

260/542

C07C 143/80 (1980.01)

Patent

CA 1145771

ABSTRACT OF THE DISCLOSURE This invention relates to new organic compounds having valuable pharmaceutical activity. It particularly relates to compounds having antihypertensive and diuretic activity and to a process for the preparation of said compounds. The invention provides compounds of the formula Image I wherein: Ar and Ar' are independently alicyclic aryl or heterocyclic aryl groups; R1 is a substituent replacing a hydrogen on the ring and is independently hydroxy, alkyl, alkoxy, halogen, nitro, amino, monoalkyl-amino, dialkyl-amino, sulfhydryl, alkyl- mercapto, sulfonamido, carboxy, carbalkoxy, or trihalomethyl; n is an integer from 0 to 5 inclusive; R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, or cycloalkyl- alkyl; and R4 and R5 are independently halogen or trihalomethyl; with the proviso that when both Ar and Ar' are phenyl and n is 0, both R2 and R3 are not hydrogen. Preferably, the alkyl, alkenyl and alkynyl groups contain up to 6 carbon atoms, and may be straight chained or branched, the cycloalkyl 2 contain from 3 to 7 carbon atoms, and Ar' is phenyl.

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