C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61P 35/04 (2006.01) C07D 295/12 (2006.01) C07D 295/125 (2006.01) C07D 319/18 (2006.01)
Patent
CA 2378600
Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
La présente invention concerne de nouveaux composés (1) de type amino-céramide qui inhibent la formation de glucosyle céramide (GlcCer) en inhibant l'enzyme GlcCer synthase et en abaissant de ce fait le taux de glycosphingolipides. Les composés de la présente invention améliorent l'activité d'inhibition de la ClcCer synthase et sont par conséquent particulièrement utiles dans les procédés thérapeutiques destinés à traiter divers états et maladies associées à une altération des taux de glycosphingolipides.
Radin Norman S.
Shayman James A.
Smart & Biggar
The Regents Of The University Of Michigan
LandOfFree
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