C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/06 (2006.01) A61K 31/16 (2006.01) A61K 31/164 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) A61P 35/00 (2006.01) C07C 233/17 (2006.01) C07D 205/04 (2006.01) C07D 211/30 (2006.01) C07D 265/30 (2006.01) C07D 295/125 (2006.01) C07D 317/58 (2006.01)
Patent
CA 2454453
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Gowling Lafleur Henderson Llp
The Regents Of The University Of Michigan
LandOfFree
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