Amino compounds and angiotensin iv receptor agonists

Details Amino compounds and angiotensin iv receptor agonists Amino compounds and angiotensin iv receptor agonists

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/135 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) A61K 31/435 (2006.01) C07C 215/54 (2006.01) C07C 323/25 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01)

Patent

CA 2242571

The present invention provides an amino compound represented by Formula: (see formula I) wherein X is CH2NH or CONH, Y is CH2NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R4)R5, CH2CH(R4)R5 or an alkoxycarbonyl group, R1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R2 and R3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R4 and R5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.

La présente invention concerne des composés représentés par la formule générale (1), ou certains de leurs sels pharmaceutiquement admis. Dans cette formule, X est CH2NH ou CONH; Y est CH2NH ou CONH, X et Y ne devant toutefois pas être simultanément CONH; Z est CH=C(R<4>)R<5>, CH2CH(R<4>)R<5> ou alcoxycarbonyl, R<4> et R<5> étant indépendamment chacun hydrogène ou alkyl éventuellement substitué, aralkyl, aryl ou hétéroaryl; R<1> est hydrogène ou alkyl inférieur éventuellement substitué, cycloalkyl, alkyl à substitution cycloalkyl, aralkyl ou aryl; enfin, R<2> et R<3> sont indépendamment chacun alkyl inférieur éventuellement substitué ou aralkyl. L'invention concerne également des médicaments comprenant les composés amino de la formule générale (1) ou certains de leurs sels pharmaceutiquement admis. L'invention concerne enfin des agonistes du récepteur de l'angiotensine IV comprenant de tels composés ou de tels sels comme principe actif. Ces médicaments conviennent comme remèdes en tant qu'antagonistes ou qu'agonistes de divers états pathologiques dans lesquels intervient l'angiotensine IV, états tels que l'accélération de la circulation sanguine rénale, la vasodilatation cérébrale, l'inhibition de la prolifération cellulaire ou l'hypermnésie.

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