Amino cyclobutylamide modulators of chemokine receptor activity

Details Amino cyclobutylamide modulators of chemokine receptor activity Amino cyclobutylamide modulators of chemokine receptor activity

C - Chemistry, Metallurgy

07

D

C07D 221/20 (2006.01) A61K 31/335 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07D 211/08 (2006.01) C07D 211/36 (2006.01) C07D 295/155 (2006.01) C07D 309/28 (2006.01) C07D 401/12 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2519220

The present invention is directed to compounds of the formulas I and II : wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R25, R26, Y, Z, l, m, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

L'invention concerne des composés représentés par les formules I et II, dans lesquelles R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?15¿, R?16¿, R?17¿, R?18¿, R?19¿, R?25¿, R?26¿, Y, Z, l, m, n et les lignes discontinues sont tels que définis dans le descriptif, qui sont utilisés comme modulateurs de l'activité du récepteur de chimiokine. En particulier, ces composés sont utilisés comme modulateurs du récepteur de chimiokine CCR-2.

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