C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/438 (2006.01) A61K 31/44 (2006.01) A61K 31/4523 (2006.01) C07D 209/02 (2006.01) C07D 221/20 (2006.01) C07D 235/04 (2006.01)
Patent
CA 2567851
Compounds of the formulae (I) and (II): (wherein Q, X, E, G1, G2, R2, R3, R4, R5, R6 and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
L'invention concerne les composés des formules (I) et (II) (Q, X, E, G1, G2, R2, R3, R4, R5, R6 et Z ayant la définition donnée) qui sont des modulateurs de l'activité du récepteur de la chimiokine et sont utiles dans la prévention ou le traitement de certains troubles et maladies inflammatoires et immuno-régulateurs, de maladies allergiques, d'états atopiques, y compris la rhinite allergique, la dermatite, la conjonctivite et l'asthme ainsi que les pathologies auto-immunes telles que l'arthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles les récepteurs de la chimiokine sont impliqués.
Guo Liangqin
Lin Songnian
Morriello Gregori
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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