Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,...

Details Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,... Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,...

C - Chemistry, Metallurgy

07

D

260/308.3

C07D 285/12 (2006.01)

Patent

CA 1128050

ABSTRACT OF THE DISCLOSURE;; The present invention relates to novel alkylamino- propanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thia- diazole corresponding to the general formula (I) Image (I) where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is un- substituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl or cycloalkenyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and their addition salts with physiologically accep- table acids. The invention is also directed to their process of preparation. These compounds thus obtained may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

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