Amino derivatives of androstanes and androstenes as...

C - Chemistry – Metallurgy – 07 – J

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) A61P 9/04 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2649175

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.

L'invention concerne des composés de formule (I) dans laquelle les groupes sont tels que définis dans le descriptif, qui sont utilisés pour la préparation de médicaments pour le traitement de troubles cardio-vasculaires, en particulier l'insuffisance cardiaque et l'hypertension. Les composés sont des inhibiteurs de l'activité enzymatique de Na+, K+-ATPase. On les utilise pour préparer un médicament destiné au traitement d'une maladie provoquée par les effets d'hypertension de l'ouabaïne endogène, par exemple la progression de l'insuffisance rénale dans la maladie rénale polycystique autosomique dominante (ADPKD), l'hypertension prééclamptique et la protéinurie et la progression de l'insuffisance rénal chez les patients présentant des polymorphismes de l'adducine.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Amino derivatives of androstanes and androstenes as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino derivatives of androstanes and androstenes as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino derivatives of androstanes and androstenes as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2030200

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.