Amino dermanol derivatives, process for their preparation...

Details Amino dermanol derivatives, process for their preparation... Amino dermanol derivatives, process for their preparation...

C - Chemistry, Metallurgy

07

D

167/208, 260/263

C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2000743

P R E C I S Nouveaux dérivés de l'amino chromanol utilisables comme médicament et répondant à la formule : Image et Image dans laquelle : . X est cyano, nitro, trifluorométhyle, alkoxycarbonyle, carbamido, dialkylcarbamido, aminosulfonyle, dialkyl- aminosulfonyle, alkylsulfonyle, alkylsulfonylamino ou acyle ; . CH2-R est fixé (en position 5 du noyau pyrrolidinone) sur un atome de carbone de configuration R ou S, et R est : - soit OR' ou SR' dans lequel R' est hydrogène, (C1-C10) alkyle, (C1-C5-alkyl)-carbonyle ou Image ; - soit Image Ces nouveaux dérivés et leurs sels physiologiquement tolé- rables sont utilisables en thérapeutique notamment dans le traitement des troubles de la régulation de la contraction du muscle lisse, dans les sphères cardiovasculaire, broncho- pulmonaire, digestive, urinaire et utérine.

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