C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) C07D 215/16 (2006.01) C07D 239/28 (2006.01) C07D 239/42 (2006.01) C07D 239/86 (2006.01)
Patent
CA 2649995
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.
La présente invention concerne de façon générale le domaine des composés thérapeutiques, et plus spécifiquement certains amino-éthyl-amino-aryles (AEAA) qui, entre autres, inhibent une protéine kinase D (PKD) (par exemple PKD1, PKD2, PKD3). La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés et l'emploi de tels composés et compositions, à la fois in vitro et in vivo, pour inhiber PKD, ainsi que dans le traitement de maladies et d'états pathologiques faisant intervenir PKD et qui sont soulagés par l'inhibition de PKD, entre autres, y compris des états pathologiques prolifératifs tels que les cancers, etc.
Carr James Lindsay
Charles Mark David
Foxton Caroline Heather
Gilliatt Julia Helen
Hammonds Timothy Robin
Cancer Research Technology Limited
Kirby Eades Gale Baker
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