Amino-heterocyclic compounds used as pde9 inhibitors

Details Amino-heterocyclic compounds used as pde9 inhibitors Amino-heterocyclic compounds used as pde9 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2748864

The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A1 and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.

La présente invention concerne des composés inhibant PDE9 de Formule (I), ainsi que leurs sels de qualité pharmaceutique, où R1, R2, R3, A1 et n sont tels que définis dans la présente invention. La présente invention concerne également des compositions pharmaceutiques contenant les composés de Formule I, ainsi que leur emploi dans le traitement de troubles neurodégénératifs et cognitifs, comme la maladie d'Alzheimer et la schizophrénie.

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