C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/47 (2006.01) C07D 207/12 (2006.01) C07D 215/14 (2006.01) C07D 405/02 (2006.01) C07D 471/02 (2006.01)
Patent
CA 2555073
Compounds of Formula I and Formula II: (wherein n, R 1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R33 R34, R35, R36, R37, R38, A, j, k, m, n, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
L'invention concerne des composés de formule I et de formule II (dans lesquelles n, R ?1¿,? ¿R?2¿, R?3¿, R4, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?15¿, R?16¿, R?17¿, R?18¿, R?19¿, R?24¿, R?25¿, R?26¿, R?27¿, R?28¿, R?29¿, R?30¿, R?33¿ R?34¿, R?35¿, R?36¿, R?37¿, R?38¿, A, j, k, m, n, X, Y et Z sont tels que définis dans la description). Lesdits composés sont des modulateurs de l'activité des récepteurs de chimiokines et sont utiles dans la prévention et le traitement de certains troubles et maladies liées à l'inflammation et à l'immunomodulation, maladies allergiques, états atopiques, notamment la rhinite allergique, la dermatite, la conjonctivite et l'asthme, ainsi que des pathologies auto-immmunes telles que la polyarthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés et compositions dans la prévention ou le traitement des maladies dans lesquelles des récepteurs de chimiokines sont impliqués.
Mills Sander G.
Pasternak Alexander
Yang Lihu
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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