Amino nicotinate derivatives as glucokinase (glk) modulators

Details Amino nicotinate derivatives as glucokinase (glk) modulators Amino nicotinate derivatives as glucokinase (glk) modulators

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2451249

The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a (A chemical formula should be inserted here - please see paper copy enclosed) Formula (I) disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

L'invention concerne de nouveaux composés représentés par la formule (I) ou un de leurs sels, solvates ou promédicaments, dans laquelle R?1¿, R?2¿, R?3¿, n et m possèdent les caractéristiques indiquées dans le descriptif. Ces composés sont utiles pour traiter une maladie ou un état, tel que le diabète de type 2, dans lesquels glucokinase (GLK) joue le rôle de médiateur. Elle concerne également des procédés servant à préparer des composés représentés par la formule (I), ainsi que leur utilisation sous forme de médicaments pour traiter des maladies dans lesquelles glucokinase joue un rôle intermédiaire.

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