Amino-phthalazinone derivatives active as kinase inhibitors,...

Details Amino-phthalazinone derivatives active as kinase inhibitors,... Amino-phthalazinone derivatives active as kinase inhibitors,...

C - Chemistry, Metallurgy

07

D

C07D 237/32 (2006.01) C07D 237/34 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2455759

Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, togetherwith pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer'sdisease, viral infections, autoimmune diseases and neurodegenerative disorders.

La présente invention concerne des composés qui sont des dérivés amino-phtalazinone représentés par la formule 1 et des sels de ceux-ci répondant aux normes pharmaceutiques, ainsi que des compositions pharmaceutiques comprenant ces composés. Ces composés et ces compositions conviennent pour le traitement de maladies causées par une activité modifiée de la protéine kinase et/ou associée à celle-ci, telle que le cancer, les troubles de la prolifération cellulaire, la maladie d'Alzheimer, des infections virales et des affections neurodégénératives.

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