Amino-pyridine, -pyridine and pyridazine derivatives for use...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) A61K 31/501 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/42 (2006.01) C07D 209/48 (2006.01) C07D 213/26 (2006.01) C07D 213/643 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 215/227 (2006.01) C07D 215/38 (2006.01) C07D 217/04 (2006.01) C07D 231/40 (2006.01) C07D 231/56 (2006.01) C07D 233/38 (2006.01) C07D 237/20 (2006.01) C07D 239/42 (2006.01) C07D 239/90 (2006.01) C07D 241/42 (2006.01) C07D

Patent

CA 2486376

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

L'invention concerne des composés représentés par la formule (I) et des compositions contenant lesdits composés permettant de traiter les douleurs inflammatoires et neurogènes aiguës, les douleurs dentaires, les céphalées générales, la céphalée vasculaire de Horton, les syndromes vasculaires mixtes et les syndromes non vasculaires, la céphalée par tension nerveuse, les inflammations générales, l'arthrose, les maladies rhumatoïdes, l'ostéoarthrite, les troubles inflammatoires des yeux, les troubles inflammatoires ou instables de la vessie, le psoriasis, les problèmes cutanés à composantes inflammatoires, les états inflammatoires chroniques, les douleurs inflammatoire associées à l'hyperalgésie et à l'allodynie, les douleurs neurogènes diabétiques, la causalgie, les douleurs continues sympathiques, les syndromes de désafférentation, l'asthme, le dysfonctionnement ou la dégradation du tissu épithélial, l'herpès simple, les perturbations de la motilité viscérale dans des régions du système respiratoire, génito-urinaire, gastro-intestinal ou vasculaire, les blessures, les brûlures, les réactions cutanées allergiques, le prurit, le vitiligo, les troubles gastro-intestinaux généraux, l'ulcère gastrique, les ulcères duodénaux, la diarrhée, les lésions gastriques induites par des agents nécrosant, la croissance capillaire, la rhinite vasomotrice ou allergique, les troubles bronchitiques ou les troubles de la vessie.

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