Amino quinazolines derivatives wuth blood platelet reducing...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/84 (2006.01) A61K 31/517 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2670168

This invention relates to the discovery of prodrugs of 3-or 5-substituted analogues of the selective platelet lowering agent anagrelide which have reduced potential for cardiovascular side-effects and which should therefore lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to prodrugs of certain imidazoquinazoline derivatives which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting the formation of blood platelet.

La présente invention concerne la découverte de promédicaments constitués d'analogues substitués en position 3 ou 5 d'anagrélide, un agent réduisant sélectivement la production des plaquettes. Ces promédicaments présentent un risque réduit d'effets secondaires cardiovasculaires et devraient par conséquent contribuer à une meilleure observance du patient à la thérapie et à une meilleure innocuité dans le traitement de maladies liées à une myéloprolifération. Plus spécifiquement, la présente invention concerne des promédicaments constitués de certains dérivés d'imidazoquinazoline qui peuvent servir d'agents réduisant la production des plaquettes chez les êtres humains. Les composés de la présente invention agissent en inhibant la formation des plaquettes sanguines.

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