C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/498 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2717171
Compounds of the Formula (I), where W represents CH or N; and Q represents - CN, -C(=NOH)NH2, -CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2. receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
L'invention concerne: des composés de formule (I). Dans cette formule (I), W désigne CH ou N; et Q désigne -CN, -C(=NOH)NH2, -CONHR1 ou des radicaux hétérocycliques variés décrits dans la description; ainsi que des sels, des solvates, des esters et des promédicaments pharmaceutiquement acceptables desdits composés. Les composés selon l'invention sont des antagonistes du récepteur A2a de l'adénosine, et sont par conséquent utiles pour traiter des maladies du système nerveux central, en particulier la maladie de Parkinson.
Hao Jinsong
Harris Joel M.
Liu Hong
Neustadt Bernard R.
Stamford Andrew W.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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