Amino-spiro¬oxa(or thia) cycloalkane-penam| - carboxylic...

Details Amino-spiro¬oxa(or thia) cycloalkane-penam| - carboxylic... Amino-spiro¬oxa(or thia) cycloalkane-penam| - carboxylic...

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/44 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1101841

ABSTRACT OF THE DISCLOSURE : Amino-spiro [oxa(or thia)cycloalkane penam] -carboxylic acid derivatives having the formula Image wherein X is a sulfur or oxygen atom or the sulfinyl group, n is 1 or 2, m is 1 or 2, R1 is hydrogen, R2 is one of the radicals known in the chemistry of the penicillins, preferably 2-phenylacetyl , 2-amino-2-phenylacetyl, 5-methyl- 3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl, or R1 and R2 together represent a bivalent radical R3, prefer- ably (hexahydro-1H-azepin-1-yl)methylene and their ther- apeutically acceptable non-toxic salts and process for preparing the same. These compounds have valuable anti- bacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-pos- itive and Gram-negative bacteria.

295138

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