Amino-substituted benzoylguanidines, process for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/155 (2006.01) A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 279/22 (2006.01) C07D 213/65 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2089442

Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Benzoylguanidines of the formula I Image are described in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH2)P- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, C1, alkyl, alkoxy, CF3, C m F2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.

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