Amino-substituted pyrazoles having crf antagonistic activity

Details Amino-substituted pyrazoles having crf antagonistic activity Amino-substituted pyrazoles having crf antagonistic activity

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01) A61K 31/395 (2006.01) C07D 231/38 (2006.01) C07D 231/44 (2006.01) C07D 231/52 (2006.01) C07D 401/00 (2006.01) C07D 401/06 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 405/06 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2150129

Substituted pyrazoles of formula (I), wherein R1, R2, R3, X, Y, Z and A are as defined herein, have contricopton-releasing factor activity. As such, they are effective in the treatment of a wide range of diseases including stress-related illnesses.

Dérivés de substitution de pyrazoles de formule (I) - où R1, R2, R3, X, Y, Z et A correspondent aux définitions données ici -, possédant une activité de facteur de libération de contricopton. Ils sont comme tels efficaces pour le traitement d'une vaste gamme de maladies, y compris celles liées au stress.

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