A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/444 (2006.01) C07D 213/72 (2006.01) C07D 401/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01)
Patent
CA 2546709
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.
La présente invention concerne des composés de pyridinyl-méthanone amino substitués, des compositions pharmaceutiques contenant ces composés, et des méthodes de synthèse s'y rapportant. Les composés de l'invention, qui sont des inhibiteurs de la kinase cycline-dépendante (CDK), peuvent être utilisés pour traiter ou améliorer des troubles induits par CDK. L'invention concerne en outre l'utilisation thérapeutique ou prophylactique des composés et/ou compositions pharmaceutiques destinée à traiter ces troubles.
Connolly Peter J.
Emanuel Stuart
Gruninger Robert H.
Lin Ronghui
Lu Yanhua
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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