Amino-substituted tricyclic derivatives and methods of use

Details Amino-substituted tricyclic derivatives and methods of use Amino-substituted tricyclic derivatives and methods of use

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) C07C 211/25 (2006.01) C07C 217/42 (2006.01) C07D 205/04 (2006.01) C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 211/46 (2006.01) C07D 243/08 (2006.01) C07D 295/10 (2006.01) C07D 333/76 (2006.01) C07D 451/06 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2555884

Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by .alpha.7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

Des composés de formule (I), dans laquelle A et B désignent des chaînes latérales à substitution amine, Y?1¿ et Y?2¿ forment différents noyaux tricycliques, X?a¿ et X?b¿ désignent C, CH, ou N tels que définis dans le descriptif et R?x¿ désigne un substituant facultatif. Des composés et de compositions de formule (I) font l'objet de cette invention ainsi que des méthodes de traitement de pathologies ou de troubles que l'on évite ou que l'on améliore grâce à des ligands .alpha.7 nAChR qui renferment des composés de formule (I) et d'autres dérivés tricycliques. Des procédés d'utilisation des dérivés tricycliques à substitution amino font également l'objet de cette invention.

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