Amino-terminally truncated mcp-2 as chemokine antagonists

Details Amino-terminally truncated mcp-2 as chemokine antagonists Amino-terminally truncated mcp-2 as chemokine antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 38/48 (2006.01) C07K 14/52 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2305017

The present invention relates to amino-terminally truncated MCP-2, lacking NH2- terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3, 1-4 or 1-5 of the naturally-occurring MCP-2 and having chemokine antagonistic activity, as well as cDNA sequences encoding them, their use in therapy and/or in diagnosis of the diseases, in which an antagonistic activity of the chemokine effects is required, and pharmaceutical compositions comprising them.

La présente invention concerne un MCP-2 à acide aminé terminal, ne possédant pas d'acides aminés à terminaison NH¿2? correspondant aux résidus d'acides aminés 1, 1-2, 1-3, 1-4 ou 1-5 du MCP-2 naturel et présentant une activité antagoniste de la chémokine, ainsi que des séquences d'ADNc codant ces derniers. L'invention concerne également leur utilisation pour traiter, et/ou diagnostiquer les maladies dans lesquelles une activité antagoniste des effets de la chémokine est requise. L'invention concerne également des compositions pharmaceutiques à base de ces composés.

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