Amino-tetrazoles analogues and methods of use

Details Amino-tetrazoles analogues and methods of use Amino-tetrazoles analogues and methods of use

C - Chemistry, Metallurgy

07

D

C07D 257/06 (2006.01) A61K 31/41 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2565211

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Un composé ayant une formule (I) ou (II) est présenté comme un antagoniste du P2X¿7?, où A, B, C, Y, Y, Z, m, v, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans la description. Les méthodes et compositions pour traiter des maladies ou troubles modulés par le P2X¿7? sont également présentées.

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