Amino-thio-acrylonitriles as mek inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 323/60 (2006.01) A61K 31/277 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 207/32 (2006.01) C07D 207/337 (2006.01) C07D 213/57 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2362380

This invention relates generally to amino-thio-acrylonitriles of formula (Ia) or (Ib) as MEK inhibitors, pharmaceutical compositions containing the same, and methods of using the same as for treatment and prevention of inflammatory disorders or as an anticancer radiosensitizing agent.

La présente invention concerne, de manière générale, des amino-thio-acrylonitriles représentés par les formules (Ia) et (Ib) et utilisés comme inhibiteurs des kinases MEK, des compositions pharmaceutiques renfermant ces composés, ainsi que des méthodes d'utilisation de ces composés pour le traitement et la prévention des troubles inflammatoires ou comme agents de radiosensibilisation anticancéreux.

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