Amino thiol peptides

Details Amino thiol peptides Amino thiol peptides

C - Chemistry, Metallurgy

07

K

530/5.04, 530/7.

C07K 5/04 (2006.01) C07C 323/44 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) C07K 5/09 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1262010

ABSTRACT AMINO THIOL PEPTIDES Analgesic and hypotensive activity is exhibited by compounds having the formula Image and pharmaceutically acceptable salts thereof, wherein R1 and R2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthio- alkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, aryl- alkyl, carbamoylalkyl, guanidinylalkyl, or hetero- aryl; R3 is hydroxy, alkoxy, (substituted alkyl)oxy, arylalkoxy, (heteroaryl)alkoxy, or -NY1Y2, wherein Y1 and Y2 are each independently hydrogen, alkyl, aryl, or arylalkyl, or Y1 is hydrogen and Y2 is substituted alkyl or (heteroaryl)alkyl; A1 is glycyl, alanyl, leucyl, phenylalanyl, arginyl, sarcosyl, seryl, asparagyl, lysyl, glutamyl, histidyl, tryptophyl, cysteinyl, methionyl, threonyl, tyrosyl, leucyl, valyl, aspartyl, prolyl, norleucyl, norvalyl, or Image wherein n6 is an integer of 2 to 15; A2, A3, A4 and A5 each is independently glycyl, alanyl, leucyl, phenylalanyl, arginyl, sarcosyl, seryl, asparagyl, lysyl, glutamyl, histidyl, tryptophyl, cysteinyl, methionyl, threonyl, tyrosyl, leucyl, valyl, aspartyl, prolyl, norleucyl, or norvalyl; and n1, n2, n3, n4 and n5 each is independently 0 or 1.

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