Aminoalcohol derivatives as beta-3 adrenergic receptor agonists

Details Aminoalcohol derivatives as beta-3 adrenergic receptor agonists Aminoalcohol derivatives as beta-3 adrenergic receptor agonists

C - Chemistry, Metallurgy

07

C

C07C 271/56 (2006.01) A61K 31/185 (2006.01) A61K 31/325 (2006.01) A61K 31/445 (2006.01) C07C 59/72 (2006.01) C07C 65/26 (2006.01) C07C 219/26 (2006.01) C07C 271/24 (2006.01) C07C 311/08 (2006.01) C07C 311/51 (2006.01) C07C 317/44 (2006.01) C07C 323/62 (2006.01) C07D 207/27 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 213/643 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01) C07D 241/24 (2006.01) C07D 30

Patent

CA 2479065

The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond,-o-o,-O-CH2-, etc., y is in which Z is bond, -0-(CH2)m- (in which m is 1 to 4), etc.,R3 is lower alkanoyl, carboxy, lower alkoxycarbonyl, etc., and R4 is hydrogen, halogen, hydroxy, phenoxy, lower alkyl, lower alkoxy, etc., and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

la présente invention concerne un composé, ou un sel de ce composé, représenté par la formule [I] dans laquelle R1 et R?5¿ sont chacun indépendamment hydrogène, halogène, alkyle inféreiur, etc., R?2¿ est hydrogène ou un groupe protecteur amino, x est une liaison,-o-o,-O-CH¿2-,?etc., y est (..) dans lequel Z est une liaison, -0-(CH¿2?)m- (où lequel m vaut de 1 à 4), etc., R?3¿ est alkanoyle inférieur, carboxy, alkoxycarbonyle inférieur, etc., et R?4¿ est hydrogène, halogène, hydroxy, phénoxy, alkyle inférieur, alkoxy inférieur, etc., et n vaut 0, 1 ou 2. Le composé [I] de l'invention et ses sels conviennent bien pour le traitement prophylactique et/ou thérapeutique de la pollakiurie ou de l'incontinence urinaire.

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