Aminoalkyl ethers of phenols as antiproliferative anticancer...

Details Aminoalkyl ethers of phenols as antiproliferative anticancer... Aminoalkyl ethers of phenols as antiproliferative anticancer...

C - Chemistry, Metallurgy

07

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167/275, 260/603

C07D 295/08 (2006.01) A61K 31/135 (2006.01) A61K 31/535 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1229604

TITLE AMINOALKYL ETHERS OF PHENOLS AS ANTICANCER AGENTS INVENTORS Lorne J. Brandes Mark W. Hermonat ABSTRACT OF THE DISCLOSURE This invention is concerned with N,N-dialkyl-2-[(4-phenyl- methyl)phenoxy]ethanamine and N-morpholino-2-[(4-phenylmethyl)phenoxy]- ethanamine compounds and their salts, and the production of these com- pounds. These compounds bind significantly to the anti-estrogen binding sites but only poorly to the estrogen receptor sites, are antiproliferative, and are cytotoxic to breast cancer cells in vitro.

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