Aminoalkyl substituted 1,2,3,4-tetrahydronaphthalenes

C - Chemistry – Metallurgy – 07 – D

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260/267.1, 260/2

C07D 295/04 (2006.01) C07D 295/096 (2006.01) C07D 295/185 (2006.01) C07D 317/70 (2006.01)

Patent

CA 1197849

AMINOALKYL SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENES Abstract of the Disclosure Aminoalkyl-mono or disubstituted naphthalenes represented by the formula Image wherein R, R1 and R2 each are the same or different members of the group consisting of hydrogen, hydroxy, loweralkoxy or halo, with the limitation that at least one of R, R1 or R2 must be other than hydrogen ex- cept in the case where R3 or R4 are phenyl-lower- alkyl or substituted phenyl-loweralkyl, or R1 and R2 or R and R1 together can form a methylenedioxy bridge; n is 1 to 4: and R3 and R4 are the same or different mem- bers of the group consisting of hydrogen, loweralkyl, haloloweralkyl, loweracyl, benzyl, phenyl-loweralkyl, substituted phenyl-loweralkyl or R3 and R4 are taken together to form a piperazino, piperidino or morpholino moiety, and the pharmaceutically acceptable acid addi- tion salts thereof. By their ability to interact specifically with various types of adrenergic and dopaminergic tissue re- ceptors, these compounds are useful as therapeutic agents in the treatment of hypertension.

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