C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2326606
Disclosed are compounds of formula (I), wherein Ar, R1, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y1 receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.
L'invention concerne des composés de la formule (I) dans laquelle Ar, R?1¿, W et X sont des substituants tels que définis dans la présente invention, ces composés étant: (1) des antagonistes de récepteurs de CRF¿1? et étant donc utiles pour le diagnostic et le traitement de troubles liés au stress tels que le syndrome de stress post-traumatique (PTSD), ainsi que la dépression, les céphalées et l'anxiété; et (2) des antagonistes de récepteurs de neuropeptide Y¿1?, ces composés étant donc utiles pour le traitement de plusieurs troubles cliniques caractérisés par la présence d'un excès de neuropeptide Y.
Darrow James W.
Horvath Raymond F.
Maynard George D.
Mbm & Co.
Neurogen Corporation
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