Aminoalkyl-substituted cycloalkylamine platinum (ii) complexes

Details Aminoalkyl-substituted cycloalkylamine platinum (ii) complexes Aminoalkyl-substituted cycloalkylamine platinum (ii) complexes

C - Chemistry, Metallurgy

07

F

167/119, 260/323

C07F 15/00 (2006.01) A61K 31/555 (2006.01)

Patent

CA 1272202

ABSTRACT Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl- substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato- ligands possess antimicrobial activity as well as activity against transplanted L1210 and P388 murine leukemia cell lines. The complexes have the general formula: Image A wherein A, X and Y are as defined in the disclosure and claims.

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