Aminoalkyl substituted urea derivatives and method of treatment

C - Chemistry – Metallurgy – 07 – D

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260/293.4, 260/3

C07D 295/14 (2006.01) C07C 275/24 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1244022

ABSTRACT Novel amino alkyl substituted urea derivatives and pharmaceutically acceptable acids of the formula Image where X and Y are the same or different and selected from a phenyl group and a substituted phenyl group with one or two groups selected from halogen, CF3, OH or alkoxyl (1-4 C atoms); and R1 and R2 are the same or different and selected from lower alkyl groups or they form together with a nitrogen atom a saturated five or six membered heterocyclic ring; R3 and R4 are each selected from hydrogen, lower alkyl or alkenyl, cyclo- pentyl or cyclohexyl and n is 0 or 1, which are made by reacting Image with an alkali metal cyanate in an aqueous acid medium.

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