Aminoalkylphenols, methods of using and making the same

Details Aminoalkylphenols, methods of using and making the same Aminoalkylphenols, methods of using and making the same

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2490243

The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.

L'invention concerne des composés aminoalkylphénol antipaludiques, obtenus par l'intermédiaire d'une base de Mannich, et leur utilisation contre des protozoaires du genre <i>Plasmodium</i>, en particulier, des souches émergentes de <i>Plasmodia</i> résistant aux médicaments. L'invention concerne en outre des compositions contenant de tels composés, ainsi qu'un procédé de fabrication de ces composés. Ce qui précède, ainsi que d'autres aspects de l'invention, ressortent de l'ensemble de la description.

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