Aminoalkylpyrrolidine serotonin receptor ligands and...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/09 (2006.01) A61K 31/40 (2006.01) A61P 25/18 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2425286

Novel aminoalkylpyrrolidine 5-HT7 receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites, or prodrugs thereof.

La présente invention concerne de nouveaux ligands des récepteurs 5-HT¿7? d'aminoalkylpyrrolidine, des procédés permettant de préparer lesdits ligands, des composés intermédiaires utiles dans la préparation des ligands de récepteurs, des compositions pharmaceutiques comprenant ces ligands de récepteurs, et des procédés permettant de traiter les troubles du sommeil, la douleur, la dépression, et la schizophrénie au moyen desdits ligands de récepteurs. Ces ligands de récepteurs ont pour formule (1): dans laquelle les variables de la formule sont telles que définies ici. L'invention porte également sur des sels, des solvates, des métabolites actifs, ou des promédicaments pharmaceutiquement acceptables, desdits ligands.

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