Aminobenzene compounds, their production and use

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 211/46 (2006.01) C07D 211/58 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2038962

Abstract of the disclosure: AMINOBENZENE COMPOUNDS, THEIR PRODUCTION AND USE A compound useful for central antioxidant having inhibitory activity of degeneration and necrocytosis of cerebral cells of the formula (I): Image (I) wherein A and B are independently (1) a group of the formula: Image wherein R1 and R2 are independently hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted heterocyclic group, or R1 together with R2 and the nitrogen atom to which they are bound may form a cyclic amino group, provided that both R1 and R2 are not hydrogen atom at the same time, or (2) a group of the formula: Image wherein D is O or S, R3 is hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group, m is 1, 2, or 3 and n is 0, 1, 2, 3 or 4; p is 1 or 2, provided that both A may be the same or different when p is 2; and R4, R5 and R6 are independently hydrogen atom, a lower alkyl or a lower alkoxy, or R5 and R6 may bond together to form -CH=CH-CH=CH-, or a salt thereof.

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