C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/315
C07D 233/02 (2006.01) A61K 31/395 (2006.01) C07D 243/08 (2006.01) C07D 245/02 (2006.01) C07D 295/04 (2006.01) C07D 295/096 (2006.01)
Patent
CA 2013037
There is disclosed an aminobenzenesulfonic acid derivative of the formula: Image wherein R1 represents hydrogen atom, a C1 - C6 alkyl group, a C3 - C7 cycloalkyl group, a C1 - C4 halogenated alkyl group, a halogen atom or a C6 - C12 aryl group, R2 represents hydrogen atom, a C1 - C6 alkyl group or a C7 C12 aralkyl group which may have at least one substituent selected from cyano group, nitro group, C1 - C6 alkoxy groups, halogen atoms, C1 - C6 alkyl groups and amino groups, and n represents an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound has an activity of inhibiting Ca2+ overload into cells and is useful as a medicine for cardiovascular diseases.
Kobayashi Makio
Morita Miyuki
Narimatsu Akihiro
Okushima Hiromi
Satoh Naoya
Mitsubishi Chemical Corporation
Smart & Biggar
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