C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2540845
The present invention discloses compounds of formula I formula I wherein Ar, Z, m, n, p, R1 and R8 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
Cette invention concerne des composés représentés par la formule I, dans laquelle Ar, Z, m, n, p, R?1¿ et R?8¿ sont tels que définis dans la description. Ces composés sont des nouveaux antagonistes pour l'hormone concentrant la mélanine (MCH). L'invention concerne également des procédés permettant de préparer de tels composés. D'autres modes de réalisation décrits dans cette invention concernent des compositions pharmaceutiques comprenant de tels antagonistes, ainsi que des méthodes permettant de les utiliser pour traiter l'obésité, les troubles métaboliques, les troubles alimentaires, tels que l'hyperphagie et les diabètes.
Burnett Duane A.
Sasikumar Thavalakulamgara K.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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