C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/254, 260/297
C07D 295/14 (2006.01) C07D 207/09 (2006.01) C07D 213/24 (2006.01) C07D 213/40 (2006.01) C07D 213/80 (2006.01) C07D 239/90 (2006.01) C07D 295/13 (2006.01) C07D 295/192 (2006.01)
Patent
CA 1108139
The object of the present invention are novel amino- benzoic acid derivatives having the general formula: Image (I), wherein R1 is hydrogen, chlorine, hydroxy, acetoxy or C1-C3-alkoxy; R2 is hydrogen, chlorine or sulfamoyl; R5 is hydrogen or combined with R6 a C2-C3-alkylene; Y is the group Image or in ortho-position together with the hydrogen atom on the nitrogen and with R5 the group Image wherein R3 is hydrogen or methyl; R4 is hydrogen, C1-C3-alkyl, or with Z substituted phenoxy; and Z is hydrogen, halogen or trifluoromethyl; X is C1-C3-alkylene forming, if necessary, under substitution with R6 a 5- or 6-link aliphatic or aromatic ring system; R6 is C1-C4-alkyl or in combination with X a C3-C4-cycloalky- lene or cycloarylene; R7 is hydrogen, C1-C3-alkyl, formyl, the group Y,or together with R6 a C4-C5-cycloalkylene, or together with X and R6 pyridylmethyl; R8 is hydrogen or, if necessary, halogen- or phenyl-substituted C1-C4-alkyl or C1-C4-alkenyl; and n has the value 0 or 1, and if n = 1, their salts with pharmaceutically compatible acid radicals. Said compounds show antilipemic activity. The present invention relates furthermore to the preparation of said compounds and of drugs containing such compounds.
306600
Metz Gunter
Specker Manfred
Fetherstonhaugh & Co.
Merckle (ludwig) K.g. Chem Pharm. Fabrik
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