Aminobenzoic acid derivatives, their preparation and their...

Details Aminobenzoic acid derivatives, their preparation and their... Aminobenzoic acid derivatives, their preparation and their...

C - Chemistry, Metallurgy

07

D

260/474.1, 260/3

C07D 295/14 (2006.01) C07D 213/53 (2006.01) C07D 295/155 (2006.01)

Patent

CA 1140934

Abstract Aminobenzoic acid derivatives are disclosed of the general formual: Image (I) whreein R1 represents a hydrogen or halogen atom, R2 and R3 each represents alkyl, cycloalkyl, phenylalkyl or pyridyl, or together represent a cyclic imino group or one of the radicals R2 and R3 represents a hydrogen atom, A represnets a cycloalkylene group or an optionally substituted or interrupted alkylene group, X represents an oxygen atom or an imino group and Y represents a hydroxy or amino group, a halogen atom, an aminobenzoyloxy or aminobenzoic acid amido group or with the .alpha.- and .beta.-carbon atoms of the radical A represents an oxiranyl or1,3-dioxolanyl group, as well as their acid addition salts. These compounds exhibit valuable pharmacological properties. Besides a secretolytic and/or antitussive activity, they especially show an antiulcus activity. Moreover, they represent intermediates for thepreparation of compounds with an antiphlogistic activity.

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