Aminobutanoic acid derivatives

Details Aminobutanoic acid derivatives Aminobutanoic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 233/63 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/385 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/65 (2006.01) C07C 233/47 (2006.01) C07C 233/83 (2006.01) C07C 235/06 (2006.01) C07C 235/16 (2006.01) C07C 235/42 (2006.01) C07C 235/52 (2006.01) C07C 237/22 (2006.01) C07C 243/34 (2006.01) C07C 255/41 (2006.01) C07C 255/57 (2006.01) C07C 259/06 (

Patent

CA 2305463

An aminobutyric acid derivative of the formula (I): Image (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an inhibitory activity on matrix metalloproteinase and are useful for prevention and / or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cells, autoimmune disease (e.g. Crohn's disease, Sjogren's syndrome), disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, aorta aneurysm, endometriosis.

L'invention concerne des dérivés d'acide aminobutanoïque représentés par la formule générale (I) et des sels de ceux-ci (chaque symbole étant tel que défini dans la description). Ces dérivés permettent d'inhiber des métalloprotéases matricielles et peuvent donc prévenir et/ou traiter les rhumatismes, l'arthrose, la résorption osseuse pathologique, l'ostéoporose, la parodontopathie, la néphrite interstitielle, l'artériosclérose, l'emphysème pulmonaire, la cirrhose du foie, les brûlures cornéennes, les maladies dues aux métastases et à l'infiltration ou à la prolifération de cellules cancéreuses, les maladies auto-immunes (par exemple la maladie de Crohn et le syndrome de Sjögren), les maladies dues à la migration ou à l'infiltration des globules blancs, la néoformation de vaisseaux sanguins, la sclérose en plaques, l'anévrisme de l'aorte, l'endométrite, et ainsi de suite.

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