Aminocarbonylcarbamates related to physostigmine, a process...

Details Aminocarbonylcarbamates related to physostigmine, a process... Aminocarbonylcarbamates related to physostigmine, a process...

C - Chemistry, Metallurgy

07

D

167/240, 260/298

C07D 487/04 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2031079

Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments The present invention relates to various derivatives related to physostigmine of the formula I (see formula I) where Z is hydrogen, halogen or loweralkyl; R1 is loweralkyl, cycloalkyl or aryl; and R2 is loweralkyl or cycloalkyl; the 3aS-cis isomer or the 3aR-isomer thereof or a mixture of the two isomers including the racemic mixture, or a pharmaceutically acceptable acid addition salt thereof, and a process for their preparation. The compounds according to the invention are useful for enhancing cholinergic function, and as analgesic agents.

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